Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569173 | 0.85 | SLC6A2 (0.43) | LMNACYP2D6TSHRHIF1AMEN1 | |
| Hydrochloric Acid SCHEMBL10569127 | 0.82 | LMNA (0.44) | LMNAMEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL1044607 | 0.82 | LMNA (0.46) | LMNACYP2D6TSHRHIF1AKDM4E | |
| SCHEMBL10571482 | 0.79 | LTA4H (0.48) | — | |
| SCHEMBL13389835 | 0.77 | NPC1 (0.54) | LMNADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10571524 | 0.77 | SLC6A2 (0.47) | — | |
| SCHEMBL1044104 | 0.77 | LMNA (0.41) | LMNACYP2D6TSHRHIF1AKDM4E | |
| SCHEMBL10475483 | 0.77 | CA1 (0.50) | TSHR | |
| SCHEMBL10565736 | 0.76 | LTA4H (0.49) | — | |
| SCHEMBL15096081 | 0.76 | PRMT5 (0.52) | LMNACYP2D6TSHRHIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104395-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009463-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-24 | — | — | WO | disclosed |