Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | HTR1B | P28222 | 9/20 | 0.53 |
| ▸ | HTR1D | P28221 | 8/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6306763 | 0.83 | HTR1A (0.57) | HTR1AHTR1BHTR1DALDH1A1TSHR | |
| SCHEMBL6306751 | 0.82 | KDM1A (0.51) | HTR1AHTR1BHTR1DTMEM97SIGMAR1 | |
| SCHEMBL7812700 | 0.81 | HTR1A (0.57) | HTR1AHTR1BHTR1DALDH1A1TSHR | |
| SCHEMBL8567402 | 0.81 | HTR1A (0.50) | HTR1AHTR1BHTR1DHRH3ALDH1A1 | |
| SCHEMBL6306100 | 0.80 | HTR1A (0.54) | HTR1AHTR1BHTR1DALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL6306223 | 0.80 | HTR1A (0.56) | HTR1AHTR1BHTR1DALDH1A1TSHR | |
| SCHEMBL8572292 | 0.79 | HRH3 (0.50) | HTR1AHTR1BHTR1DHRH3MEN1 | |
| SCHEMBL9058832 | 0.79 | HTR1A (0.65) | HTR1AHTR1BHTR1DALDH1A1GAA | |
| SCHEMBL6312894 | 0.78 | HTR1A (0.75) | HTR1AHTR1BHTR1DHRH3ALDH1A1 | |
| SCHEMBL11862997 | 0.78 | KMT2A (0.66) | ALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767782-B1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER (US) | 2001-10-31 | — | — | EP | disclosed |
| CN-1064350-C | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 2001-04-11 | — | — | CN | disclosed |
| US-6166020-A | Aryl and heteroaryl alkoxynaphthalene derivatives | PFIZER INC. (US) | 2000-12-26 | — | — | US | disclosed |
| US-5821245-A | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0795328-A1 | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| CN-1151729-A | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 1997-06-11 | — | — | CN | disclosed |
| EP-0767782-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000720-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1996-01-11 | — | — | WO | disclosed |