Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273901 | 0.84 | CDK8 (0.63) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL8790338 | 0.82 | CDK8 (0.63) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL10879740 | 0.80 | CDK8 (0.67) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL3999705 | 0.80 | CDK8 (0.74) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL26710460 | 0.80 | CDK8 (0.57) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL8789349 | 0.79 | CDK8 (0.72) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL9426326 | 0.79 | CDK8 (0.68) | CDK8CLK4RAB9ANPC1L3MBTL1 | |
| SCHEMBL8789844 | 0.78 | CDK8 (0.58) | CDK8CLK4KMT2ARAB9ANPC1 | |
| SCHEMBL14276933 | 0.77 | CYP3A4 (0.66) | CDK8CLK4KMT2ARAB9AL3MBTL1 | |
| SCHEMBL10411628 | 0.77 | ATM (0.58) | CYP1A2CYP3A4CYP2D6BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663395-B1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | SOLVAY PHARM GMBH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-5679699-A | ANTIISCHEMIC AGENTS, HEART RATE LOWERING AGENTS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-10-21 | — | — | US | disclosed |
| US-5547967-A | HYPOTENSIVE AGENT, ANTIISCHEMIC AGENT | KALI-CHEMIE PHARMA GMBH (DE) | 1996-08-20 | — | — | US | disclosed |
| EP-0663395-A1 | 3-(phenylalkylaminoalkyloxy)-5-phenylpyrazole derivatives, process and intermediates for their preparation and their use as cardiac rhythm reduction agent | Kali-Chemie Pharma GmbH (DE) | 1995-07-19 | — | — | EP | disclosed |