Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789349 | 0.93 | CDK8 (0.72) | CDK8CLK4CYP19A1RAB9ANPC1 | |
| SCHEMBL8789814 | 0.89 | CYP19A1 (0.56) | CDK8CLK4CYP19A1L3MBTL1AOC3 | |
| SCHEMBL8790404 | 0.86 | CDK8 (0.60) | CDK8CLK4CYP19A1RAB9ANPC1 | |
| SCHEMBL8790877 | 0.86 | CYP19A1 (0.55) | CDK8CLK4CYP19A1L3MBTL1PLAAT3 | |
| SCHEMBL8790474 | 0.85 | ALOX5 (0.66) | AOC3ALDH1A1HTTLTB4RLTB4R2 | |
| SCHEMBL8789844 | 0.84 | CDK8 (0.58) | CDK8CLK4RAB9ANPC1L3MBTL1 | |
| SCHEMBL7273901 | 0.83 | CDK8 (0.63) | CDK8CLK4RAB9ANPC1L3MBTL1 | |
| SCHEMBL8789786 | 0.82 | CDK8 (0.56) | CDK8CLK4CYP19A1RAB9AAOC3 | |
| SCHEMBL7809238 | 0.82 | CDK8 (0.64) | CDK8CLK4RAB9ANPC1L3MBTL1 | |
| SCHEMBL3999705 | 0.81 | CDK8 (0.74) | CDK8CLK4RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |