SCHEMBL7809356

SCHEMBL7809356

Nc1cnn2c(NCCO)ccnc12.Nc1cnn2ccc(O)nc12

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SMPD3 Q9NY59 13/20 0.37
RET P07949 2/20 0.33
IRAK4 Q9NWZ3 2/20 0.32
PIM1 P11309 1/20 0.30
FLT3 P36888 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL126959 0.86 SMPD3 (0.35) SMPD3FLT3
SCHEMBL3275922 0.80 SMPD3 (0.45) SMPD3
SCHEMBL127192 0.75 SMPD3 (0.57) SMPD3PIM1
SCHEMBL7456528 0.70 HRH3 (0.46) PIM1
SCHEMBL2849820 0.67 SMPD3 (0.34) SMPD3
SCHEMBL3946877 0.66 KMT2A (0.50)
Hydrochloric Acid SCHEMBL8150702 0.65 KMT2A (0.49)
SCHEMBL7595938 0.65 TERT (0.38)
SCHEMBL3339272 0.65 SMPD3 (0.37) SMPD3
SCHEMBL457580 0.64 GPR119 (0.33) SMPD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1137391-A1 METHOD FOR TREATING HAIR Novozymes A/S (DK) 2001-10-04 EP disclosed
WO-2000032158-A1 METHOD FOR TREATING HAIR NOVOZYMES A/S (DK) 2000-06-08 WO disclosed