Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480041 | 0.86 | CYP3A4 (0.47) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL14214508 | 0.81 | AHR (0.57) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL24611517 | 0.76 | AHR (0.55) | MAPTCYP3A4AHRCYP1A2CYP2C9 | |
| SCHEMBL24367843 | 0.75 | AHR (0.50) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL4241023 | 0.74 | AHR (0.48) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL7915043 | 0.73 | AHR (0.52) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL19059390 | 0.70 | AHR (0.44) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL6627835 | 0.69 | AHR (0.57) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL154593 | 0.68 | AHR (1.00) | MAPTCYP3A4AHRHTR6CYP1A2 | |
| SCHEMBL29420757 | 0.68 | AHR (1.00) | MAPTCYP3A4AHRHTR6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773932-B1 | BENZENESULFONAMIDE DERIVATIVES USED AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2001-09-26 | — | — | EP | disclosed |
| EP-0773932-A1 | BENZENESULFONAMIDE DERIVATIVES USED AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996040639-A1 | BENZENESULFONAMIDE DERIVATIVES USED AS BRADYKININE ANTAGONISTS | FOURNIER INDUSTRIE ET SANTE (FR) | 1996-12-19 | — | — | WO | disclosed |