Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809588 | 1.00 | DRD2 (0.42) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7819654 | 0.91 | HTR7 (0.46) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7819652 | 0.91 | HTR7 (0.46) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7823988 | 0.87 | DRD2 (0.47) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7809287 | 0.83 | HTR7 (0.39) | DRD2DRD4DRD3HTR7HTR1A | |
| SCHEMBL7809285 | 0.83 | HTR7 (0.39) | DRD2DRD4DRD3HTR7HTR1A | |
| SCHEMBL7825216 | 0.77 | HTR7 (0.42) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7823496 | 0.77 | HTR7 (0.49) | DRD2DRD4DRD5DRD3HTR7 | |
| SCHEMBL7822734 | 0.75 | HTR2A (0.52) | HTR7HTR2AHTR6 | |
| SCHEMBL7822736 | 0.75 | HTR2A (0.52) | HTR7HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294677-B1 | HAS SEROTONIN-2-RECEPTER ANTAGONISTIC ACTION AND USEFUL AS A DRUG FOR PREVENTING OR TREATING ISCHEMIC HEART DISEASES, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE, WITH MINIMAL TOXIC OR SIDE EFFECTS | SUNTORY LIMITED (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0749971-B1 | Thiopyran derivatives | SUNTORY LTD (JP) | 2001-03-14 | — | — | EP | disclosed |
| US-6100265-A | BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE | SUNTORY LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5977111-A | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0749971-A1 | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1996-12-27 | — | — | EP | disclosed |