Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815944 | 0.82 | GRIN2D (0.56) | SIGMAR1LTA4HALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3815948 | 0.82 | GRIN2D (0.56) | SIGMAR1LTA4HALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL27780998 | 0.82 | SIGMAR1 (0.51) | SIGMAR1LTA4HALDH1A1KMT2AF2 | |
| SCHEMBL16714074 | 0.82 | GRIN2D (0.56) | SIGMAR1LTA4HALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7808456 | 0.80 | SIGMAR1 (0.49) | SIGMAR1LTA4HALDH1A1KMT2AF2 | |
| SCHEMBL15148260 | 0.80 | F2 (0.48) | SIGMAR1LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL10684577 | 0.80 | SIGMAR1 (0.49) | SIGMAR1LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL8563102 | 0.80 | F2 (0.48) | SIGMAR1LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL3494724 | 0.80 | F2 (0.52) | SIGMAR1LTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL1307820 | 0.79 | SIGMAR1 (0.58) | SIGMAR1LTA4HALDH1A1FUCA1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0727421-B1 | Agents for improving sleep | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |
| EP-0727421-A1 | Agents for improving sleep | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-21 | — | — | EP | disclosed |
| US-5026853-A | Sleep and cardiovascular disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-06-25 | — | — | US | disclosed |
| US-4968684-A | N-ARYL-PIPERAZINEALKANAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-11-06 | — | — | US | disclosed |
| US-4880808-A | SEDATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-11-14 | — | — | US | disclosed |
| EP-0285219-A2 | Method of improving sleep | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-10-05 | — | — | EP | disclosed |