SCHEMBL7810079

SCHEMBL7810079

CC(C)(Oc1ccc(C2=CCN(C(=O)c3cc(I)c(O)c(I)c3)CC2)cc1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 4/20 0.49
PPARG P37231 3/20 0.49
NAMPT P43490 5/20 0.41
QDPR P09417 2/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
POLB P06746 2/20 0.40
ALOX15 P16050 1/20 0.40
ITGB3 P05106 1/20 0.39
ITGA2B P08514 1/20 0.39
MAPT P10636 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7810085 0.90 PPARG (0.48) PPARAPPARGNAMPTQDPRALDH1A1
SCHEMBL9011204 0.89 PPARA (0.48) PPARAPPARGNAMPTQDPRALDH1A1
SCHEMBL7813581 0.87 PPARA (0.51) PPARAPPARGNAMPTALDH1A1POLB
SCHEMBL7804727 0.86 PPARG (0.53) PPARAPPARGNAMPTALDH1A1HPGD
SCHEMBL7804408 0.85 PPARA (0.53) PPARAPPARGNAMPTALDH1A1POLB
SCHEMBL7811809 0.84 NAMPT (0.57) PPARAPPARGNAMPTQDPRALDH1A1
SCHEMBL7811694 0.84 PPARG (0.52) PPARAPPARGNAMPTALDH1A1ITGB3
SCHEMBL7811461 0.83 NAMPT (0.52) PPARAPPARGNAMPTALDH1A1HPGD
SCHEMBL7813924 0.83 PPARA (0.51) PPARAPPARGNAMPTHPGDPOLB
SCHEMBL7817567 0.83 PPARA (0.64) PPARAPPARGNAMPTALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed