Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.55 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818005 | 1.00 | HSD11B1 (0.55) | HSD11B1SOAT1KCNH2POLBMEN1 | |
| SCHEMBL1388689 | 0.77 | HSD11B1 (0.51) | HSD11B1MEN1KMT2AALDH1A1 | |
| SCHEMBL13956661 | 0.76 | TRPV1 (0.43) | HSD11B1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL23975119 | 0.76 | POLB (0.70) | HSD11B1SOAT1KCNH2POLBMEN1 | |
| SCHEMBL1388808 | 0.75 | HSD11B1 (0.48) | HSD11B1SOAT1POLBMEN1KMT2A | |
| SCHEMBL8103610 | 0.71 | HSD11B1 (1.00) | HSD11B1SOAT1KCNH2POLBGFER | |
| SCHEMBL19850690 | 0.71 | HSD11B1 (0.60) | HSD11B1SOAT1KCNH2POLBMEN1 | |
| SCHEMBL7814794 | 0.71 | HSD11B1 (0.54) | HSD11B1KCNH2POLBMEN1KMT2A | |
| SCHEMBL5697557 | 0.68 | HSD11B1 (0.51) | HSD11B1SOAT1KCNH2POLBMEN1 | |
| SCHEMBL1997854 | 0.67 | L3MBTL1 (0.56) | HSD11B1POLBMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681569-B1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORP (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0681569-A1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017038-A1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1994-08-04 | — | — | WO | disclosed |