Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810876 | 0.92 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7813676 | 0.81 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7810247 | 0.81 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL5753264 | 0.77 | LTA4H (0.57) | RAB9ANPC1SMN1; SMN2MAPK1SERPINE1 | |
| SCHEMBL13097024 | 0.76 | MAPK1 (0.64) | SMN1; SMN2LMNAMAPK1ALDH1A1MAOB | |
| SCHEMBL7801915 | 0.76 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7813674 | 0.74 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL15552182 | 0.74 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL7801917 | 0.74 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL471098 | 0.73 | PPARG (0.62) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820990-B1 | Benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR (FR) | 2001-01-17 | — | — | EP | disclosed |
| US-5972968-A | INTERLEUKIN INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-10-26 | — | — | US | disclosed |
| EP-0820990-A2 | Novel benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR ET COMPAGNIE (FR) | 1998-01-28 | — | — | EP | disclosed |