Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 6/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815098 | 0.94 | FGFR1 (0.44) | FGFR1PDE2AGPBAR1CYSLTR1LTA4H | |
| SCHEMBL7805179 | 0.88 | FGFR1 (0.50) | FGFR1PDE2ACYP19A1CYP3A4CYP2D6 | |
| SCHEMBL7814303 | 0.88 | MAPT (0.48) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7815075 | 0.87 | FGFR1 (0.43) | FGFR1PDE2ACYP19A1CYP3A4CYP2D6 | |
| SCHEMBL7812089 | 0.82 | FGFR1 (0.50) | FGFR1GPBAR1CYSLTR1LTA4H | |
| SCHEMBL7815337 | 0.79 | ALDH1A1 (0.43) | PDE2ACYP1A2ALDH1A1MAPK1 | |
| SCHEMBL7805459 | 0.78 | NPC1 (0.49) | CYP3A4HRH3 | |
| SCHEMBL7810877 | 0.78 | FGFR1 (0.49) | FGFR1PDE2ACYP19A1CYP3A4CYP2D6 | |
| SCHEMBL7814533 | 0.77 | GPBAR1 (0.36) | FGFR1PDE2AGPBAR1CYSLTR1 | |
| SCHEMBL7805417 | 0.75 | BRD4 (0.47) | FGFR1PDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |