Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812504 | 0.89 | NPC1 (0.52) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL7814303 | 0.81 | MAPT (0.48) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL7814533 | 0.70 | GPBAR1 (0.36) | — | |
| SCHEMBL5448369 | 0.70 | MEN1 (0.53) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL21803205 | 0.70 | ACSS2 (0.66) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL29408381 | 0.70 | ACSS2 (0.46) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL2176865 | 0.70 | ALOX5 (0.58) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL2362005 | 0.69 | CYP3A4 (0.51) | NPC1RAB9AMEN1KMT2AACSS2 | |
| SCHEMBL1855831 | 0.69 | MAOB (0.62) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL8305195 | 0.69 | AS3MT (0.50) | NPC1RAB9AMEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |