Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190261 | 0.88 | LMNA (0.51) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL8191460 | 0.86 | LMNA (0.49) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL8192774 | 0.86 | LMNA (0.49) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL8190067 | 0.86 | LMNA (0.49) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL8191893 | 0.85 | LMNA (0.48) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL8196364 | 0.83 | LMNA (0.47) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL27369574 | 0.83 | LMNA (0.46) | GLALMNAMAPTKDM4EGRIK1 | |
| SCHEMBL7814569 | 0.80 | LMNA (0.51) | GLALMNAMAPTKDM4EL3MBTL1 | |
| SCHEMBL7807447 | 0.79 | LMNA (0.45) | GLALMNAMAPTL3MBTL1PKM | |
| SCHEMBL8189990 | 0.78 | LMNA (0.55) | LMNAMAPTKDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784054-B1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVES AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMA CO LTD (JP) | 2001-11-28 | — | — | EP | disclosed |
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |