Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190261 | 0.84 | LMNA (0.51) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8192774 | 0.82 | LMNA (0.49) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8191460 | 0.82 | LMNA (0.49) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8190067 | 0.82 | LMNA (0.49) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8139111 | 0.82 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8191893 | 0.81 | LMNA (0.48) | LMNAMAPTALDH1A1KDM4EGLA | |
| SCHEMBL8196364 | 0.80 | LMNA (0.47) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL7811079 | 0.80 | GLA (0.53) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8191290 | 0.80 | LMNA (0.43) | LMNAMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL8203993 | 0.79 | MAPT (0.49) | MAPTALDH1A1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784054-B1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVES AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMA CO LTD (JP) | 2001-11-28 | — | — | EP | disclosed |
| CN-1067387-C | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 2001-06-20 | — | — | CN | disclosed |