Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 6/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.50 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12400619 | 0.85 | LTB4R (0.40) | LTB4RLTB4R2CYP4F2CYP4A11MAOB | |
| SCHEMBL5114053 | 0.82 | LTB4R (0.54) | LTB4RLTB4R2CYP4F2CYP4A11MAOB | |
| SCHEMBL5104714 | 0.81 | FFAR1 (0.52) | LTB4RLTB4R2CYP4F2CYP4A11MAOB | |
| SCHEMBL5518178 | 0.79 | AOC3 (0.54) | ALOX5PTGESTSPO | |
| SCHEMBL5116145 | 0.78 | LTB4R (0.53) | LTB4RLTB4R2CYP4F2CYP4A11BCHE | |
| SCHEMBL17361052 | 0.78 | LTB4R2 (0.47) | LTB4R2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL26986003 | 0.77 | LTB4R (0.74) | LTB4RLTB4R2CYP4F2CYP4A11MAOB | |
| SCHEMBL3660617 | 0.75 | FFAR1 (0.66) | LTB4RLTB4R2CYP4F2CYP4A11MAOB | |
| SCHEMBL5519402 | 0.75 | ACHE (0.57) | — | |
| SCHEMBL5106882 | 0.74 | LTB4R (0.58) | LTB4RLTB4R2MAOBBCHEALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163225-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055137-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |