SCHEMBL7811458

SCHEMBL7811458

CC(C)(Oc1ccc(C2=CCN(C(=O)c3ccc4ccccc4n3)CC2)cc1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.47
ALDH1A1 P00352 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
PPARG P37231 6/20 0.46
PPARA Q07869 6/20 0.46
TSHR P16473 1/20 0.45
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
PPARD Q03181 1/20 0.43
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41
RAB9A P51151 1/20 0.41
GRIN2B Q13224 1/20 0.40
PDE10A Q9Y233 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
NAMPT P43490 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7814229 0.91 ALDH1A1 (0.46) GAAALDH1A1SMN1; SMN2PPARGPPARA
SCHEMBL7804727 0.82 PPARG (0.53) ALDH1A1SMN1; SMN2PPARGPPARACYP2C9
SCHEMBL7813847 0.80 PPARG (0.55) ALDH1A1SMN1; SMN2PPARGPPARACYP2C9
SCHEMBL7811390 0.80 GAA (0.73) GAAALDH1A1SMN1; SMN2PPARATSHR
SCHEMBL7817532 0.80 ALDH1A1 (0.41) GAAALDH1A1SMN1; SMN2PPARGPPARA
SCHEMBL7811694 0.79 PPARG (0.52) ALDH1A1SMN1; SMN2PPARGPPARAL3MBTL1
SCHEMBL7810133 0.78 GAA (0.51) GAAALDH1A1SMN1; SMN2PPARATSHR
SCHEMBL7804408 0.77 PPARA (0.53) ALDH1A1SMN1; SMN2PPARGPPARACYP2C19
SCHEMBL7811809 0.77 NAMPT (0.57) GAAALDH1A1PPARGPPARANAMPT
SCHEMBL7817135 0.77 NAMPT (0.55) ALDH1A1SMN1; SMN2PPARGPPARAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed