SCHEMBL781157

SCHEMBL781157

c1ccc(-c2ccc3oc4c(-c5ccc6c7ccc(-c8cc(-c9ccccc9)cc9c8oc8ccc(-c%10ccccc%10)cc89)cc7n(-c7ccc(-c8c9ccccc9c(-c9ccccc9)c9ccccc89)cc7)c6c5)cc(-c5ccccc5)cc4c3c2)cc1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 3/20 0.35
PLA2G4A P47712 3/20 0.35
ALOX5 P09917 1/20 0.33
PIM1 P11309 1/20 0.32
CSNK2A2 P19784 1/20 0.32
CSNK2B P67870 1/20 0.32
PIM3 Q86V86 1/20 0.32
PIM2 Q9P1W9 1/20 0.32
PRKDC P78527 3/20 0.32
PLA2G10 O15496 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ATM Q13315 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SIRT2 Q8IXJ6 1/20 0.31
SIRT1 Q96EB6 1/20 0.31
CYP1A1 P04798 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP1B1 Q16678 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL781014 0.99 PLA2G2A (0.34) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781099 0.98 KDM4E (0.35) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781192 0.97 KDM4E (0.35) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL15745740 0.96 PLA2G2A (0.34) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781108 0.94 PLA2G2A (0.33) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL780983 0.93 PLA2G2A (0.33) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL780843 0.93 PLA2G2A (0.33) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781072 0.93 KDM4E (0.35) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781043 0.92 KDM4E (0.36) PLA2G2APLA2G4AALOX5PIM1CSNK2A2
SCHEMBL781816 0.92 KDM4E (0.36) PLA2G2APLA2G4AALOX5PIM1CSNK2A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 PLA2G2A 4705/4885PLA2G4A 4695/4885ALOX5 1162/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 PLA2G2A 4705/4885PLA2G4A 4695/4885ALOX5 1162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.