SCHEMBL7811644

SCHEMBL7811644

CC(C)(Oc1cccc(C2CCN(C(=O)c3ccc4ccccc4n3)CC2)c1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 13/20 0.52
CTNNB1 P35222 13/20 0.52
TSHR P16473 1/20 0.47
GAA P10253 1/20 0.46
PPARA Q07869 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7810133 0.89 GAA (0.51) TSHRGAAPPARA
SCHEMBL9011040 0.88 BCL9 (0.45) BCL9CTNNB1TSHRGAAPPARA
SCHEMBL7804335 0.83 TSHR (0.67) TSHRGAA
SCHEMBL7814374 0.82 BCL9 (0.54) BCL9CTNNB1PPARA
SCHEMBL7817510 0.80 BCL9 (0.57) BCL9CTNNB1PPARA
SCHEMBL7810746 0.77 BCL9 (0.56) BCL9CTNNB1PPARA
SCHEMBL7810100 0.77 BCL9 (0.56) BCL9CTNNB1PPARA
SCHEMBL7811390 0.77 GAA (0.73) TSHRGAAPPARA
SCHEMBL7814025 0.77 HSD11B1 (0.63) BCL9CTNNB1TSHRGAAPPARA
SCHEMBL7813329 0.77 BCL9 (0.56) BCL9CTNNB1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed