Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840334 | 0.82 | PLAU (0.49) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL7807789 | 0.81 | HDAC6 (0.52) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL7815687 | 0.78 | APP (0.47) | PLAUPLGGRIN2BHDAC8HDAC6 | |
| SCHEMBL7084091 | 0.76 | PLAU (0.50) | PLAUPLGGRIN2BEGFRERBB4 | |
| SCHEMBL31661458 | 0.76 | PLAU (0.50) | PLAUPLGGRIN2BEGFRERBB4 | |
| SCHEMBL7803164 | 0.76 | SRC (0.43) | PLAUPLGGRIN2BEGFRERBB4 | |
| SCHEMBL14093199 | 0.76 | GABRA1 (0.52) | GRIN2BEGFRERBB4MAOBSRC | |
| SCHEMBL7809472 | 0.74 | KMT2A (0.60) | PLAUGRIN2BHDAC8HDAC6HDAC1 | |
| SCHEMBL7811905 | 0.74 | NTSR1 (0.42) | GRIN2BHDAC8HDAC6HDAC11EGFR | |
| SCHEMBL7815339 | 0.73 | NPC1 (0.50) | GRIN2BHDAC8HDAC6HDAC11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0949259-B1 | N-HYDROXYUREA DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-6184238-B1 | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-02-06 | — | — | US | disclosed |
| EP-0949259-A1 | N-HYDROXYUREA DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-10-13 | — | — | EP | disclosed |