Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800915 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL7614772 | 0.80 | L3MBTL1 (0.43) | SMN1; SMN2MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL27903061 | 0.69 | MAPK9 (0.39) | MAPK9MAPK10MAPK14 | |
| SCHEMBL12411162 | 0.69 | MAPK8 (0.47) | SMN1; SMN2MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL27903059 | 0.66 | MAPK9 (0.39) | MAPK9MAPK10BRAFKDRMAPK14 | |
| SCHEMBL84061 | 0.66 | MAPK9 (0.43) | MAPK9MAPK10KDRMAPK14 | |
| SCHEMBL21797185 | 0.66 | KMT2A (0.43) | SMN1; SMN2MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL4490400 | 0.66 | AURKA (0.54) | KMT2AMAPTRAB9AKDRNPC1 | |
| SCHEMBL4399077 | 0.66 | SYK (0.37) | MAPK9KMT2AMAPTRAB9AKDR | |
| SCHEMBL13306228 | 0.66 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802908-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0802908-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021654-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-18 | — | — | WO | disclosed |