Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135383 | 0.77 | PKM (0.54) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL7135386 | 0.77 | PKM (0.54) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL17730555 | 0.77 | PKM (0.54) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL4699004 | 0.75 | PKM (0.65) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL4699000 | 0.75 | PKM (0.65) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL5363714 | 0.74 | PKM (0.60) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL5363709 | 0.74 | PKM (0.60) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL5363715 | 0.74 | PKM (0.60) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL8429766 | 0.72 | LMNA (0.52) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL8429769 | 0.72 | LMNA (0.52) | PKMLMNAALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119566-A1 | NOVEL HETEROCYCLYL-METHYL-SUBSTITUTED PYRAZOLES | Bayer Aktiengesellschaft (DE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021954-A1 | NOVEL HETEROCYCLYL-METHYL-SUBSTITUTED PYRAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-04-20 | — | — | WO | disclosed |