Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 7/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6774752 | 0.80 | CCR3 (0.68) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6774750 | 0.80 | CCR3 (0.68) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7669574 | 0.78 | CCR3 (0.80) | CCR3SLC6A4SLC6A2SLC6A3POLB | |
| SCHEMBL7669580 | 0.78 | CCR3 (0.80) | CCR3SLC6A4SLC6A2SLC6A3POLB | |
| SCHEMBL18844418 | 0.78 | CCR3 (0.77) | CCR3SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL6773025 | 0.78 | CCR3 (0.74) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7658588 | 0.77 | CCR3 (0.90) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7658592 | 0.77 | CCR3 (0.90) | CCR3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL27666282 | 0.77 | GBA1 (0.59) | CCR3SLC6A4SLC6A2SLC6A3GBA1 | |
| SCHEMBL18840912 | 0.77 | CCR3 (1.00) | CCR3SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140833-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035876-A1 | 2-SUBSTITUTED-4-NITROGEN HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |