Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104163 | 1.00 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1TRPV1MEN1KMT2A | |
| SCHEMBL5256815 | 1.00 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1TRPV1MEN1KMT2A | |
| SCHEMBL11106258 | 1.00 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1TRPV1MEN1KMT2A | |
| SCHEMBL5250174 | 1.00 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1TRPV1MEN1KMT2A | |
| SCHEMBL1270020 | 0.98 | SIGMAR1 (0.59) | SIGMAR1L3MBTL1TRPV1MEN1KMT2A | |
| SCHEMBL2074321 | 0.92 | SIGMAR1 (0.59) | SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL349780 | 0.84 | ALDH1A1 (0.52) | SIGMAR1L3MBTL1 | |
| SCHEMBL11103198 | 0.81 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1 | |
| SCHEMBL11107579 | 0.81 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1 | |
| SCHEMBL5254490 | 0.80 | HRH1 (0.57) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077929-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061410-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |