Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.38 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.62 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL2231959 | 0.94 | — | — | |
| Glycine SCHEMBL318020 | 0.90 | — | — | |
| Glycine SCHEMBL29244710 | 0.90 | GLRA1 (0.77) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL907052 | 0.90 | GLRA1 (0.77) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL11291516 | 0.90 | GLRA1 (0.77) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL7918812 | 0.90 | GLRA1 (0.77) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL5535262 | 0.88 | GLRA1 (0.62) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL19208039 | 0.88 | GLRA1 (0.62) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL1285648 | 0.87 | GLRA1 (0.71) | OR51E2GLRA1SLC6A9FFAR3HDAC3 | |
| Glycine SCHEMBL20854478 | 0.87 | GLRA1 (0.71) | OR51E2GLRA1SLC6A9FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305624-B1 | Self-degradable explosive device | MAXAMCORP HOLDING SL (ES) | 2017-09-27 | — | — | EP | claimed |
| EP-2931278-A1 | ORAL FORM, COMPRISING IMMEDIATE-RELEASE COATED PARTICLES OF AT LEAST ONE ACTIVE COMPOUND THAT ARE GRINDING-RESISTANT | Flamel Ireland Limited (IE) | 2015-10-21 | — | — | EP | claimed |
| US-9149439-B2 | Multi-particulate, modified-release composition | SANDOZ AG (CH) | 2015-10-06 | — | — | US | claimed |
| WO-2014091437-A1 | ORAL FORM, COMPRISING IMMEDIATE-RELEASE COATED PARTICLES OF AT LEAST ONE ACTIVE COMPOUND THAT ARE GRINDING-RESISTANT | FLAMEL TECHNOLOGIES (FR) | 2014-06-19 | — | — | WO | claimed |
| US-8585841-B2 | Systems and methods for chemical and/or mechanical remediation of nitro compounds and nitrate esters | MAXAMCORP HOLDING S.L. (ES) | 2013-11-19 | — | — | US | claimed |
| EP-2445852-A1 | SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS | Maxamcorp Holding, S.L. (ES) | 2012-05-02 | — | — | EP | claimed |
| EP-2305624-A1 | Self-degradable explosive formulations | Maxamcorp Holding, S.L. (ES) | 2011-04-06 | — | — | EP | claimed |
| US-20110041718-A1 | SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS | MAXAMCORP HOLDING S.L. (ES) | 2011-02-24 | — | — | US | claimed |
| WO-2010149750-A1 | SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS | MAXAMCORP HOLDING S.L. (ES) | 2010-12-29 | — | — | WO | claimed |
| US-5540945-A | Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1996-07-30 | — | — | US | claimed |
| CN-116669665-A | Intragastric expandable device | 意比图密医疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-112469398-A | Pharmaceutical dosage form for oral administration with a sustained release effect | 拜耳公司 | 2021-03-09 | — | — | CN | disclosed |
| EP-2305624-B1 | Self-degradable explosive device | MAXAMCORP HOLDING SL (ES) | 2017-09-27 | — | — | EP | disclosed |
| US-20150328168-A1 | ORAL FORM, COMPRISING IMMEDIATE-RELEASE COATED PARTICLES OF AT LEAST ONE ACTIVE COMPOUND THAT ARE GRINDING-RESISTANT | FLAMEL IRELAND LIMITED (IE) | 2015-11-19 | — | — | US | disclosed |
| EP-2931278-A1 | ORAL FORM, COMPRISING IMMEDIATE-RELEASE COATED PARTICLES OF AT LEAST ONE ACTIVE COMPOUND THAT ARE GRINDING-RESISTANT | Flamel Ireland Limited (IE) | 2015-10-21 | — | — | EP | disclosed |
| US-5126142-A | Sustained release of antibiotics to livestock | ALZA CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0483273-A1 | DISPENSER COMPRISING IONOPHORE. | ALZA CORP (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0425699-A1 | ORAL PREPARATION WHICH CAN BE RELEASED AT SUITABLE REGION IN INTESTINE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-05-08 | — | — | EP | disclosed |
| WO-1991001131-A1 | DISPENSER COMPRISING IONOPHORE | ALZA CORPORATION (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4186184-A | Selective administration of drug with ocular therapeutic system | ALZA CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |