Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.32 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.32 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.62 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL5535262 | 1.00 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL723130 | 0.94 | — | — | |
| Glycine SCHEMBL468791 | 0.94 | OR51E2 (0.71) | GLRA1SLC6A9OR51E2FFAR3GABRR1 | |
| Glycine SCHEMBL30204 | 0.94 | OR51E2 (0.71) | GLRA1SLC6A9OR51E2FFAR3GABRR1 | |
| Glycine SCHEMBL28367785 | 0.90 | — | — | |
| Glycine SCHEMBL2418117 | 0.90 | OR51E2 (0.67) | GLRA1SLC6A9OR51E2FFAR3GABRR1 | |
| Glycine SCHEMBL907052 | 0.90 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL7918812 | 0.90 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL11291516 | 0.90 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK | |
| Glycine SCHEMBL29244710 | 0.90 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411343-A1 | SEMI-HUMIC ORGANIC CARBON MATERIAL AND METHODS OF USE THEREOF | Actagro LLC (US) | 2018-12-12 | — | — | EP | claimed |
| WO-2017136566-A1 | SEMI-HUMIC ORGANIC CARBON MATERIAL AND METHODS OF USE THEREOF | ACTAGRO, LLC (US) | 2017-08-10 | — | — | WO | claimed |
| EP-3455194-A1 | SEMI-HUMIC COMPOSITION AND METHODS OF USE THEREOF | Actagro LLC (US) | 2019-03-20 | — | — | EP | disclosed |
| EP-3411343-A1 | SEMI-HUMIC ORGANIC CARBON MATERIAL AND METHODS OF USE THEREOF | Actagro LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| US-20180057419-A1 | SEMI-HUMIC ORGANIC CARBON MATERIAL AND METHODS OF USE THEREOF | ACTAGRO, LLC | 2018-03-01 | — | — | US | disclosed |
| WO-2017196890-A1 | SEMI-HUMIC COMPOSITION AND METHODS OF USE THEREOF | ACTAGRO, LLC (US) | 2017-11-16 | — | — | WO | disclosed |
| WO-2017136566-A1 | SEMI-HUMIC ORGANIC CARBON MATERIAL AND METHODS OF USE THEREOF | ACTAGRO, LLC (US) | 2017-08-10 | — | — | WO | disclosed |