Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 8/20 | 0.77 |
| ▸ | HTR3B | O95264 | 8/20 | 0.77 |
| ▸ | HTR3A | P46098 | 8/20 | 0.77 |
| ▸ | HTR3D | Q70Z44 | 8/20 | 0.77 |
| ▸ | HTR3C | Q8WXA8 | 8/20 | 0.77 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 4/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 3/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885159 | 0.88 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL5034246 | 0.82 | HTR3E (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL5471239 | 0.81 | HTR3E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL1363670 | 0.80 | HTR3E (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL3250038 | 0.80 | HTR3E (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL2862598 | 0.80 | HTR3E (0.77) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL1368 | 0.80 | HTR3E (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL2913167 | 0.80 | HTR3E (0.79) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Nitric Acid SCHEMBL5733225 | 0.80 | HTR3E (0.79) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Phenylguanidine SCHEMBL6129042 | 0.78 | PLAU (0.71) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| CN-1047776-C | Pharmacologically active pyridine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 1999-12-29 | — | — | CN | disclosed |
| US-5728708-A | ANTITUMOR AGENTS | NOVARTIS CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| CN-1115982-A | pyridine derivatives having pharmacological activity and preparation method thereof | CIBA GEIGY AG (CH) | 1996-01-31 | — | — | CN | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |