Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylguanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.71 |
| ▸ | SLC22A2 | O15244 | 5/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.71 |
| ▸ | HTR3B | O95264 | 4/20 | 0.71 |
| ▸ | HTR3A | P46098 | 4/20 | 0.71 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.71 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.71 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.71 |
| ▸ | SLC22A3 | O75751 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylguanidine SCHEMBL467577 | 0.84 | SLC22A2 (1.00) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Phenylguanidine SCHEMBL28899228 | 0.82 | SLC22A2 (0.85) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Phenylguanidine SCHEMBL11092912 | 0.82 | SLC22A2 (0.94) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Phenylguanidine SCHEMBL4739913 | 0.82 | SLC22A2 (0.94) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL6033862 | 0.82 | CA12 (0.72) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL4613845 | 0.80 | PLAU (0.73) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL1833741 | 0.80 | PLAU (0.73) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL2544085 | 0.80 | PLAU (0.73) | PLAUSLC22A2HTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL3860515 | 0.80 | PLAU (0.92) | PLAUPOLBNOS1NOS3PRSS1 | |
| Nitric Acid SCHEMBL5471239 | 0.80 | HTR3E (0.49) | PLAUSLC22A2HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234090-B1 | SILVER HALIDE PHOTOGRAPHIC EMULSIONS WITH NOVEL GRAIN FACES (1) | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1991-07-31 | — | — | EP | claimed |
| US-11780858-B2 | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | SPRINT BIOSCIENCE AB (SE) | 2023-10-10 | — | — | US | disclosed |
| CN-116041320-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-116041321-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-4169581-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | Sprint Bioscience AB (SE) | 2023-04-26 | — | — | EP | disclosed |
| EP-3672948-B1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-10-05 | — | — | EP | disclosed |
| US-20220177495-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2022-06-09 | — | — | US | disclosed |
| US-11208423-B2 | Pyridinamine-pyridone and pyrimidinamine- pyridone compounds | SPRINT BIOSCIENCE AB (SE) | 2021-12-28 | — | — | US | disclosed |
| US-20200361963-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2020-11-19 | — | — | US | disclosed |
| EP-3672948-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | Sprint Bioscience AB (SE) | 2020-07-01 | — | — | EP | disclosed |
| EP-1187816-A1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | Celltech R&D Limited (GB) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078731-A1 | 5-CYANO-2-AMINOPYRIMIDINE DERIVATIVES | CELLTECH R&D LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |
| CN-1043531-C | Pyrimidine derivatives and a process for production thereof | NOVATIS AG (CH) | 1999-06-02 | — | — | CN | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |
| EP-0347866-B1 | ANILINOPYRIMIDINE DERIVATIVES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1993-04-07 | — | — | EP | disclosed |
| EP-0270111-B1 | PYRIMIDINE DERIVATIVES AND AGRICULTURAL OR HORTICULTURAL FUNGICIDAL COMPOSITION CONTANING THE SAME | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4992438-A | Pyrimidine derivatives, process for preparing the same and agricultural or horticultural fungicidal composition containing the same | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-02-12 | — | — | US | disclosed |
| US-4943675-A | Anilinopyrimidine derivatives | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1990-07-24 | — | — | US | disclosed |
| EP-0347866-A2 | Anilinopyrimidine derivatives | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1989-12-27 | — | — | EP | disclosed |
| EP-0270111-A1 | Pyrimidine derivatives and agricultural or horticultural fungicidal composition contaning the same | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780858-B2 | Pyridinamine-pyridone and pyrimidinamine-pyridone compounds | PDXK, PLPBP, PNPO | PLAU 2938/4885SLC22A2 1955/4885HTR3E 1982/4885 |
| US-11208423-B2 | Pyridinamine-pyridone and pyrimidinamine- pyridone compounds | PDXK, PLPBP, PNPO | PLAU 2866/4885SLC22A2 1909/4885HTR3E 1973/4885 |
| US-20220177495-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | PDXK, PLPBP, PNPO | PLAU 2938/4885SLC22A2 1955/4885HTR3E 1982/4885 |
| US-20200361963-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | PDXK, PLPBP, PNPO | PLAU 2866/4885SLC22A2 1909/4885HTR3E 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.