Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 3/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560321 | 0.86 | FKBP1A (0.57) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL11489453 | 0.84 | TMEM97 (0.53) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL14836799 | 0.84 | CTSK (0.58) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL7284521 | 0.84 | SMN1; SMN2 (0.54) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL26151546 | 0.82 | FKBP1A (0.55) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL2768429 | 0.82 | PREP (0.60) | SMN1; SMN2NPC1RAB9APREPACE2 | |
| SCHEMBL16105052 | 0.82 | FKBP1A (0.50) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL4117187 | 0.81 | SMN1; SMN2 (0.52) | FKBP1ASMN1; SMN2NPC1RAB9APREP | |
| SCHEMBL18477527 | 0.81 | FKBP1A (0.52) | FKBP1APREPTMEM97SIGMAR1 | |
| SCHEMBL25678381 | 0.81 | FKBP1A (0.62) | FKBP1APREPCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1996005193-A1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |