Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.57 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814298 | 0.84 | KEAP1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL26159161 | 0.79 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7825360 | 0.77 | KEAP1 (0.55) | MCL1C5AR1KEAP1NFE2L2 | |
| SCHEMBL12407000 | 0.77 | MEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6831270 | 0.76 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6518997 | 0.74 | KEAP1 (0.65) | PPARGKEAP1NFE2L2 | |
| SCHEMBL6399954 | 0.73 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6831152 | 0.73 | C5AR1 (0.76) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19638954 | 0.73 | MEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19892767 | 0.73 | SMN1; SMN2 (0.58) | MCOLN3KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |