Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | C5AR1 | P21730 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814298 | 0.94 | KEAP1 (0.52) | KEAP1NFE2L2ALDH1A1KMT2AC5AR1 | |
| SCHEMBL1688338 | 0.86 | KMT2A (0.63) | KEAP1NFE2L2ALDH1A1KMT2AC5AR1 | |
| SCHEMBL7826084 | 0.84 | ALDH1A1 (0.64) | KEAP1NFE2L2ALDH1A1KMT2AMAPT | |
| SCHEMBL14502622 | 0.82 | KEAP1 (0.66) | KEAP1NFE2L2KMT2AMAPTPTGES | |
| SCHEMBL12406996 | 0.80 | MEN1 (0.57) | KEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL7813686 | 0.77 | PSEN1 (0.57) | KEAP1NFE2L2C5AR1MCL1 | |
| SCHEMBL7813347 | 0.77 | ATM (0.53) | KEAP1NFE2L2ALDH1A1KMT2AC5AR1 | |
| SCHEMBL7613742 | 0.76 | C5AR1 (0.49) | KEAP1NFE2L2KMT2AC5AR1MAPT | |
| SCHEMBL13589964 | 0.75 | KEAP1 (0.55) | KEAP1NFE2L2ALDH1A1SMN1; SMN2PTGES | |
| SCHEMBL1495969 | 0.75 | TP53 (0.52) | ALDH1A1KMT2AMAPTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |