Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTPRG | P23470 | 5/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841746 | 0.86 | PLAU (0.41) | PTPRCKMT2APTPRGBCAT2AR | |
| Hydrochloric Acid SCHEMBL7357455 | 0.84 | PLAU (0.40) | PTPRCKMT2APTPRGBCAT2AR | |
| SCHEMBL7246054 | 0.77 | KMT2A (0.56) | PTPRCKMT2APTPRGLMNAMAPT | |
| Trifluoroacetic Acid SCHEMBL27554832 | 0.70 | DPP4 (0.37) | KMT2ABCAT2MAPTF2 | |
| Trifluoroacetic Acid SCHEMBL5658568 | 0.70 | GSK3B (0.46) | KMT2ABCAT2MAPTGAAHPGD | |
| Trifluoroacetic Acid SCHEMBL5223272 | 0.70 | PLAU (0.72) | PLAUKLK1KLK5F2 | |
| SCHEMBL7886053 | 0.69 | KMT2A (0.39) | PTPRCKMT2APTPRGARLMNA | |
| Trifluoroacetic Acid SCHEMBL5223817 | 0.67 | DAO (0.50) | KMT2ALMNAALDH1A1GAAHPGD | |
| SCHEMBL20504888 | 0.65 | ALDH1A1 (0.34) | KMT2ABCAT2MAPTKDM4EALDH1A1 | |
| Benzamidine SCHEMBL5241617 | 0.63 | F2 (0.67) | KMT2AMAPTKLK1KLK5F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1152759-A2 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047194-A9 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | DIMENSIONAL PHARM INC (US) | 2001-05-31 | — | — | WO | disclosed |
| WO-2000047194-A2 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |