Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814225 | 1.00 | NPBWR1 (0.58) | NPBWR1MCHR1SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7618359 | 0.99 | NPBWR1 (0.57) | NPBWR1MCHR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1815987 | 0.96 | NPBWR1 (0.53) | NPBWR1MCHR1KDM4ECD274PDCD1 | |
| SCHEMBL3148367 | 0.96 | NPBWR1 (0.53) | NPBWR1MCHR1KDM4ECD274PDCD1 | |
| SCHEMBL2030130 | 0.96 | NPBWR1 (0.53) | NPBWR1MCHR1KDM4ECD274PDCD1 | |
| SCHEMBL3713831 | 0.87 | SMN1; SMN2 (0.63) | MCHR1SMN1; SMN2CD274MEN1KMT2A | |
| SCHEMBL16714062 | 0.87 | SMN1; SMN2 (0.63) | MCHR1SMN1; SMN2CD274MEN1KMT2A | |
| SCHEMBL3713829 | 0.87 | SMN1; SMN2 (0.63) | MCHR1SMN1; SMN2CD274MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2500262 | 0.86 | SMN1; SMN2 (0.61) | MCHR1SMN1; SMN2CD274MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7742897 | 0.86 | SMN1; SMN2 (0.61) | MCHR1SMN1; SMN2CD274MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035852-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-09-12 | — | — | EP | claimed |
| EP-1035852-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-09-20 | — | — | EP | claimed |
| WO-1999027933-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1035852-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1035852-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5972966-A | AND THE FARNESYLATION OF THE ONCOGENE PROTEIN RAS | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999027933-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |