SCHEMBL1815987

SCHEMBL1815987

O=C(O)[C@@H]1CCCN1Cc1cccc(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPBWR1 P48145 1/20 0.53
MCHR1 Q99705 1/20 0.53
CYP1A2 P05177 1/20 0.52
SPHK1 Q9NYA1 1/20 0.52
F2 P00734 3/20 0.51
SLC6A9 P48067 2/20 0.51
SIGMAR1 Q99720 1/20 0.50
CD274 Q9NZQ7 2/20 0.49
PDCD1 Q15116 1/20 0.49
KDM4E B2RXH2 1/20 0.49
ATM Q13315 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
CCR4 P51679 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2030130 1.00 NPBWR1 (0.53) NPBWR1MCHR1CYP1A2SPHK1F2
SCHEMBL3148367 1.00 NPBWR1 (0.53) NPBWR1MCHR1CYP1A2SPHK1F2
SCHEMBL7814221 0.96 NPBWR1 (0.58) NPBWR1MCHR1SIGMAR1CD274PDCD1
SCHEMBL7814225 0.96 NPBWR1 (0.58) NPBWR1MCHR1SIGMAR1CD274PDCD1
Hydrochloric Acid SCHEMBL7618359 0.95 NPBWR1 (0.57) NPBWR1MCHR1F2CD274PDCD1
SCHEMBL7309417 0.88 SPHK1 (0.63) NPBWR1MCHR1SPHK1F2CD274
SCHEMBL6508602 0.87 MAOB (0.65) SPHK1CD274PDCD1
SCHEMBL6508605 0.87 MAOB (0.65) SPHK1CD274PDCD1
SCHEMBL1819248 0.87 CYP1A2 (0.60) MCHR1CYP1A2SPHK1CD274PDCD1
SCHEMBL1972076 0.87 CYP1A2 (0.60) MCHR1CYP1A2SPHK1CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154568-A1 NON-CANONICAL INSULINS AND THEIR USES California Institute of Technology (US) 2017-04-19 EP claimed
WO-2015191705-A1 NON-CANONICAL INSULINS AND THEIR USES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-12-17 WO claimed
US-20150353619-A1 Non-Canonical Insulins and Their Uses CALIFORNIA INSTITUTE OF TECHNOLOGY 2015-12-10 US claimed
US-20250249074-A1 GLUCOSE RESPONSIVE INSULINS PROTOMER TECHNOLOGIES INC. 2025-08-07 US disclosed
EP-4525919-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS Protomer Technologies Inc. (US) 2025-03-26 EP disclosed
US-12214018-B2 Glucose responsive insulins PROTOMER TECHNOLOGIES, INC. (US) 2025-02-04 US disclosed
US-20240425528-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS PROTOMER TECH INC (US) 2024-12-26 US disclosed
US-20240400637-A1 COMPOUNDS CONTAINING ONE OR MORE DIBORONATES AND RELATED INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. 2024-12-05 US disclosed
US-20240374735-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. 2024-11-14 US disclosed
US-12139502-B2 Aromatic boron-containing compounds and related insulin analogs PROTOMER TECHNOLOGIES INC. (US) 2024-11-12 US disclosed
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto BACH BIOSCIENCES, LLC (US) 2024-07-02 US disclosed
WO-2008119005-A1 3,4-DEHYDRO-PROLINE-CONTAINING INHIBITORS OF DIPEPTIDYLPEPTIDASE IV TRUSTEES OF TUFTS COLLEGE (US) 2008-10-02 WO disclosed
WO-2008116053-A2 FAP-ACTIVATED CHEMOTHERAPEUTIC COMPOUNDS, AND METHODS OF USE THEREOF TRUSTEES OF TUFTS COLLEGE (US) 2008-09-25 WO disclosed
WO-2008116054-A1 INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN, AND METHODS OF USE THEREOF TRUSTEES OF TUFTS COLLEGE (US) 2008-09-25 WO disclosed
EP-1948243-A2 POLYCATION-POLYANION COMPLEXES, COMPOSITIONS AND METHODS OF USE THEREOF Aeris Therapeutics, Inc. (US) 2008-07-30 EP disclosed
US-20080057491-A1 Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2008-03-06 US disclosed
WO-2008022015-A2 RETRO-INVERSO INCRETIN ANALOGUES, AND METHODS OF USE THEREOF TRUSTEES OF TUFTS COLLEGE (US) 2008-02-21 WO disclosed
WO-2007146104-A2 SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE MCKEE PATRICK A (US) 2007-12-21 WO disclosed
WO-2007055950-A2 POLYCATION-POLYANION COMPLEXES, COMPOSITIONS AND METHODS OF USE THEREOF AERIS THERAPEUTICS, INC. (US) 2007-05-18 WO disclosed
US-20070110813-A1 Polycation-polyanion complexes, compositions and methods of use thereof AERIS THERAPEUTICS, INC. (US) 2007-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250249074-A1 GLUCOSE RESPONSIVE INSULINS GLP1R, GPR119, IAPP NPBWR1 112/4885MCHR1 106/4885CYP1A2 4240/4885
US-20240425528-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS IAPP, GPR119, INSR NPBWR1 160/4885MCHR1 1951/4885CYP1A2 4014/4885
US-12214018-B2 Glucose responsive insulins GLP1R, GPR119, IAPP NPBWR1 113/4885MCHR1 107/4885CYP1A2 4191/4885
US-20150353619-A1 Non-Canonical Insulins and Their Uses IAPP, IDE, INSR NPBWR1 148/4885MCHR1 2762/4885CYP1A2 2895/4885
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto FAP, FIBP, GOT1 NPBWR1 3549/4885MCHR1 4812/4885CYP1A2 2416/4885
US-20240400637-A1 COMPOUNDS CONTAINING ONE OR MORE DIBORONATES AND RELATED INSULIN ANALOGS GPR119, INSR, IAPP NPBWR1 203/4885MCHR1 223/4885CYP1A2 1802/4885
US-12139502-B2 Aromatic boron-containing compounds and related insulin analogs IAPP, GPR119, INSR NPBWR1 160/4885MCHR1 1951/4885CYP1A2 4014/4885
US-20240374735-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND INSULIN ANALOGS IAPP, GPR119, BRCA1 NPBWR1 73/4885MCHR1 86/4885CYP1A2 1240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.