Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609623 | 0.84 | MAOA (0.58) | MAOAMAOB | |
| SCHEMBL15684283 | 0.84 | S1PR1 (0.50) | POLBMAOAMAOBL3MBTL1S1PR1 | |
| SCHEMBL16499815 | 0.82 | ALDH1A1 (0.52) | MAOAMAOBALDH1A1MAPT | |
| SCHEMBL16499642 | 0.82 | ALDH1A1 (0.52) | MAOAMAOBALDH1A1MAPT | |
| SCHEMBL16499644 | 0.82 | ALDH1A1 (0.52) | MAOAMAOBALDH1A1MAPT | |
| SCHEMBL12449905 | 0.82 | MAOA (0.50) | MAOAMAOB | |
| SCHEMBL1662783 | 0.81 | GBA1 (0.53) | POLBL3MBTL1ALDH1A1GAAPLG | |
| SCHEMBL3515654 | 0.81 | GBA1 (0.53) | POLBL3MBTL1ALDH1A1GAAPLG | |
| SCHEMBL10619913 | 0.81 | S1PR3 (0.57) | S1PR1S1PR5ALDH1A1MAPT | |
| SCHEMBL10619909 | 0.81 | S1PR3 (0.57) | S1PR1S1PR5ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681569-B1 | SPIROCYCLOALKYL-SUBSTITUTED AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORP (US) | 2001-03-21 | — | — | EP | disclosed |
| US-5698548-A | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents | SCHERING CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |
| CN-1118163-A | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents | SCHERING CORP (US) | 1996-03-06 | — | — | CN | disclosed |