SCHEMBL7814536

SCHEMBL7814536

Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)O)c3Cl)c2n1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 13/20 0.74
BDKRB2 P30411 7/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7814538 1.00 RORC (0.74) RORCBDKRB2
SCHEMBL7951569 0.92 RORC (0.64) RORCBDKRB2
SCHEMBL7951571 0.92 RORC (0.64) RORCBDKRB2
SCHEMBL7815597 0.90 RORC (0.65) RORCBDKRB2
SCHEMBL7013096 0.89 RORC (0.76) RORCBDKRB2
SCHEMBL7805295 0.89 BDKRB2 (0.67) RORCBDKRB2
SCHEMBL7805291 0.89 BDKRB2 (0.67) RORCBDKRB2
SCHEMBL7812765 0.89 RORC (0.71) RORCBDKRB2
SCHEMBL7952877 0.89 BDKRB2 (0.61) RORCBDKRB2
SCHEMBL7805546 0.89 RORC (0.65) RORCBDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787131-B1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-10-31 EP disclosed
EP-0925295-B1 N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS B2 RECEPTOR ANTAGONISTS OF THE BRADYKININ FOURNIER IND & SANTE (FR) 2001-10-04 EP disclosed
EP-0874841-B1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-10-04 EP disclosed
US-6211181-B1 ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIALLERGENS, AND ANTIASTHMATICS FOURNIER INDUSTRIE ET SANTE (FR) 2001-04-03 US disclosed
US-6080758-A ANALGESICS, ANTIINFLAMMATORY AGENTS; ASTHMA; ALLERGIC RHINITIS FOURNIER INDUSTRIE ET SANTE (FR) 2000-06-27 US disclosed
US-6071917-A ANALGESICS; ANTIINFLAMMATORY AGENTS; ESPECIALLY FOR THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS; COMPETITIVE BINDING AT RECEPTORS FOURNIER INDUSTRIE ET SANTE (FR) 2000-06-06 US disclosed
EP-0925295-A1 N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS BRADYKININ B2 AGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1999-06-30 EP disclosed
EP-0874841-A1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR B2 ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1998-11-04 EP disclosed
WO-1998003503-A1 N-BENZENESULPHONYL-L-PROLINE DERIVATIVES AS BRADYKININ B2 AGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1998-01-29 WO disclosed
EP-0787131-A1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-08-06 EP disclosed
WO-1997024349-A1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-07-10 WO disclosed
WO-1997007115-A1 BENZENESULPHONAMIDE DERIVATIVES AS BRADYKININE ANTAGONISTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-02-27 WO disclosed