Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807803 | 0.86 | HTR1A (0.62) | DRD2HTR1ACYP2D6DRD4DRD3 | |
| SCHEMBL16702063 | 0.85 | DRD2 (0.61) | DRD2HTR1ACYP2D6DRD4DRD3 | |
| SCHEMBL7815137 | 0.85 | HTR1A (0.61) | DRD2HTR1ACYP2D6DRD4DRD3 | |
| SCHEMBL13533015 | 0.82 | HTR1A (0.81) | DRD2HTR1A | |
| SCHEMBL31052147 | 0.78 | HTR1A (0.39) | DRD2HTR1ADRD4DRD3ALDH1A1 | |
| SCHEMBL31051815 | 0.77 | DRD2 (0.39) | DRD2HTR1ADRD4DRD3ALDH1A1 | |
| SCHEMBL13533020 | 0.76 | HTR1A (1.00) | DRD2HTR1ACYP2D6DRD4DRD3 | |
| SCHEMBL31051833 | 0.76 | DRD2 (0.38) | DRD2HTR1ADRD4DRD3ALDH1A1 | |
| SCHEMBL31052184 | 0.76 | DRD2 (0.55) | DRD2HTR1ADRD4DRD3ALDH1A1 | |
| SCHEMBL7807446 | 0.75 | DRD2 (0.52) | DRD2HTR1ACYP2D6DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633260-B1 | 2,3-Dihydro-1,4-benzodioxan-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INT RES (NL) | 2001-11-07 | — | — | EP | disclosed |
| US-5462942-A | 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| EP-0633260-A1 | 2,3-Dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-01-11 | — | — | EP | disclosed |