Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317974 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDNQO2ELANE | |
| SCHEMBL29532076 | 0.84 | KDM4E (0.54) | KDM4EALDH1A1HPGDNQO2ELANE | |
| SCHEMBL30344059 | 0.78 | POLB (0.50) | KDM4EALDH1A1HPGDNQO2 | |
| SCHEMBL899079 | 0.78 | POLB (0.50) | KDM4EALDH1A1HPGDNQO2 | |
| SCHEMBL7811233 | 0.75 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDPARP1NQO2 | |
| SCHEMBL4748400 | 0.75 | MAPT (0.52) | PARP1ELANEGRIN1GRIN2AACHE | |
| SCHEMBL26607337 | 0.75 | PARP1 (0.43) | PARP1ELANEGRIN1GRIN2AACHE | |
| SCHEMBL7811084 | 0.74 | PARP1 (0.46) | PARP1ELANEGRIN1GRIN2AACHE | |
| SCHEMBL31140889 | 0.74 | PARP1 (0.46) | PARP1ELANEGRIN1GRIN2AACHE | |
| SCHEMBL28705074 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320051-B1 | AMINO(NH) OR OXYGEN(O) SUBSTITUTED, ENZYME INHIBITORS OF STAPHLOCCOCUS AUREUS METHIONYL T-RNA SYNTHETASE (MRS); ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-20 | — | — | US | disclosed |
| CN-1307565-A | Quinolones used as MRS inhibitor and bactericides | SMITHKLINE BEECHAM PLC (GB) | 2001-08-08 | — | — | CN | disclosed |
| EP-1084110-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999055677-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 1999-11-04 | — | — | WO | disclosed |