Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 10/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL781503 | 1.00 | SCNN1A (0.34) | SCNN1AALDH1A1GHSRPOLBENPP2 | |
| SCHEMBL782978 | 0.93 | SCNN1A (0.34) | SCNN1AALDH1A1GHSRPOLBENPP2 | |
| SCHEMBL782976 | 0.93 | SCNN1A (0.34) | SCNN1AALDH1A1GHSRPOLBENPP2 | |
| SCHEMBL781987 | 0.91 | SCNN1A (0.34) | SCNN1AALDH1A1GHSRPOLBMEN1 | |
| SCHEMBL781989 | 0.91 | SCNN1A (0.34) | SCNN1AALDH1A1GHSRPOLBMEN1 | |
| SCHEMBL781784 | 0.91 | SCNN1A (0.35) | SCNN1AALDH1A1GHSRPOLBMEN1 | |
| SCHEMBL781786 | 0.91 | SCNN1A (0.35) | SCNN1AALDH1A1GHSRPOLBMEN1 | |
| SCHEMBL782165 | 0.89 | POLB (0.43) | SCNN1AALDH1A1GHSRPOLB | |
| SCHEMBL782167 | 0.89 | POLB (0.43) | SCNN1AALDH1A1GHSRPOLB | |
| SCHEMBL806915 | 0.89 | SCNN1A (0.40) | SCNN1AALDH1A1GHSRPOLBENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071479-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | US | claimed |
| US-20120071479-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071479-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | REN, SCNN1B, SCN5A | SCNN1A 6/4885ALDH1A1 2428/4885GHSR 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.