Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.58 |
| ▸ | TDO2 | P48775 | 4/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815486 | 0.85 | IDO1 (0.57) | IDO1TDO2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7808047 | 0.84 | IDO1 (0.79) | IDO1TDO2ALDH1A1MEN1KMT2A | |
| SCHEMBL7805816 | 0.82 | IDO1 (0.53) | IDO1TDO2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7808401 | 0.80 | IDO1 (0.57) | IDO1TDO2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7805503 | 0.79 | MAOA (0.44) | IDO1TDO2MAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL7812573 | 0.76 | IDO1 (0.53) | IDO1TDO2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL22732884 | 0.76 | IDO1 (0.63) | IDO1TDO2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7813200 | 0.74 | MAOA (0.44) | IDO1TDO2MAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL7816954 | 0.74 | IDO1 (1.00) | IDO1TDO2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8595445 | 0.73 | IDO1 (0.82) | IDO1TDO2TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |