Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.57 |
| ▸ | TDO2 | P48775 | 4/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808401 | 0.95 | IDO1 (0.57) | IDO1TDO2PTGS2SMN1; SMN2USP8 | |
| SCHEMBL7815358 | 0.85 | IDO1 (0.58) | IDO1TDO2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7805816 | 0.83 | IDO1 (0.53) | IDO1TDO2PTGS2SMN1; SMN2FGFR1 | |
| SCHEMBL7808047 | 0.82 | IDO1 (0.79) | IDO1TDO2PTGS2ALDH1A1CDC7 | |
| SCHEMBL7805852 | 0.80 | ADORA2A (0.41) | IDO1TDO2SMN1; SMN2USP8ALDH1A1 | |
| SCHEMBL7812573 | 0.78 | IDO1 (0.53) | IDO1TDO2PTGS2SMN1; SMN2FGFR1 | |
| SCHEMBL7808005 | 0.76 | IDO1 (0.60) | IDO1TDO2PTGS2SMN1; SMN2USP8 | |
| SCHEMBL7805807 | 0.76 | IDO1 (0.60) | IDO1TDO2PTGS2SMN1; SMN2USP8 | |
| SCHEMBL22732884 | 0.75 | IDO1 (0.63) | IDO1TDO2PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL7815082 | 0.74 | ADORA2A (0.41) | IDO1TDO2SMN1; SMN2USP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |