Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | RB1 | P06400 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408588 | 1.00 | OPRM1 (0.39) | OPRM1OPRK1CDKN1ACYP2D6SIRT1 | |
| SCHEMBL8408464 | 0.85 | CYP2D6 (0.34) | OPRM1OPRK1CYP2D6ATM | |
| SCHEMBL7818295 | 0.78 | HTR2B (0.41) | SIRT1MEN1KMT2AHTR2B | |
| SCHEMBL8408620 | 0.76 | HTR2B (0.56) | SIRT1MEN1KMT2AHTR2B | |
| SCHEMBL7820113 | 0.76 | HTR2B (0.56) | SIRT1MEN1KMT2AHTR2B | |
| SCHEMBL7820110 | 0.76 | HTR2B (0.56) | SIRT1MEN1KMT2AHTR2B | |
| Hydrochloric Acid SCHEMBL8684280 | 0.71 | HTR2B (0.58) | HTR2B | |
| Hydrochloric Acid SCHEMBL8684071 | 0.71 | HTR2B (0.58) | HTR2B | |
| SCHEMBL7816458 | 0.67 | MCHR1 (0.40) | SIRT1GAACASP6RECQLSIRT2 | |
| SCHEMBL7828495 | 0.67 | MCHR1 (0.40) | SIRT1GAACASP6RECQLSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749313-A4 | METHOD FOR TREATING 5HT 2B RECEPTOR RELATED CONDITIONS | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| US-5663178-A | 5-HT2 RECEPTOR ANTABONISTS | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5643916-A | 5-HT(2B) RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5629317-A | SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1997-05-13 | — | — | US | disclosed |
| EP-0749313-A1 | METHOD FOR TREATING 5HT 2B RECEPTOR RELATED CONDITIONS | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996024351-A1 | TETRAHYDRO-BETA-CARBOLINES, OCTAHYDRO-INDOLO-[2,3-c]QUINOLINES AND OCTAHYDRO-INDOLO-[2,3-c]-QUINUCLIDINES | ELI LILLY AND COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| WO-1995024200-A1 | METHOD FOR TREATING 5HT2B RECEPTOR RELATED CONDITIONS | ELI LILLY AND COMPANY (US) | 1995-09-14 | — | — | WO | disclosed |