Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.60 |
| ▸ | MAOA | P21397 | 5/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674540 | 0.90 | MAOB (0.71) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL8710346 | 0.88 | MAOB (0.69) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL6993494 | 0.87 | MAOB (0.59) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL669237 | 0.82 | MAOB (0.65) | MAOBMAOANR4A2CYP4F2CYP4A11 | |
| SCHEMBL8366338 | 0.80 | NFE2L2 (0.54) | MAOBMAOAPKM | |
| SCHEMBL6987590 | 0.80 | MAOB (0.54) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL6987856 | 0.79 | MAOB (0.56) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL8840811 | 0.78 | NFE2L2 (0.52) | MAOBMAOAPKM | |
| SCHEMBL7813380 | 0.78 | MAOB (0.63) | MAOBMAOALCKCYP4F2CYP4A11 | |
| Isothiocyanate SCHEMBL28295717 | 0.77 | MAOB (0.55) | MAOBMAOANR4A2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163225-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055137-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |