Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840811 | 0.90 | NFE2L2 (0.52) | NFE2L2MAOAMAOBNPC1RAB9A | |
| SCHEMBL5941183 | 0.86 | NFE2L2 (0.50) | NFE2L2MAOAMAOBNPC1RAB9A | |
| SCHEMBL154188 | 0.86 | NFE2L2 (0.55) | NFE2L2MAOAMAOBNPC1RAB9A | |
| SCHEMBL9187662 | 0.82 | NFE2L2 (0.59) | NFE2L2MAOAMAOBNPC1RAB9A | |
| SCHEMBL28126527 | 0.81 | NFE2L2 (0.61) | NFE2L2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL7817239 | 0.80 | MAOB (0.60) | MAOAMAOBPKM | |
| SCHEMBL8325508 | 0.77 | NFE2L2 (0.55) | NFE2L2MAOAMAOBNPC1RAB9A | |
| SCHEMBL23457236 | 0.77 | NFE2L2 (0.60) | NFE2L2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL16618839 | 0.77 | NFE2L2 (0.60) | NFE2L2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL167999 | 0.77 | TAAR1 (0.52) | NFE2L2MAOAMAOBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929217-A4 | SORDARIN DERIVATIVES | MERCK & CO INC (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0929217-A1 | SORDARIN DERIVATIVES | Merck & Co., Inc. (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998015178-A1 | SORDARIN DERIVATIVES | MERCK & CO., INC. (US) | 1998-04-16 | — | — | WO | disclosed |