SCHEMBL7817263

SCHEMBL7817263

Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4C[C@H](O)C[C@H]4C(=O)N4CCN(C(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)CC4)c3Cl)c2n1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 12/20 0.54
BDKRB2 P30411 8/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7817264 1.00 RORC (0.54) RORCBDKRB2
SCHEMBL7817260 1.00 RORC (0.54) RORCBDKRB2
SCHEMBL7815355 0.92 RORC (0.62) RORCBDKRB2
SCHEMBL7815354 0.92 RORC (0.62) RORCBDKRB2
SCHEMBL7811065 0.88 RORC (0.59) RORCBDKRB2
SCHEMBL7811063 0.88 RORC (0.59) RORCBDKRB2
SCHEMBL7815353 0.86 BDKRB2 (0.61) RORCBDKRB2
SCHEMBL7815349 0.86 BDKRB2 (0.61) RORCBDKRB2
SCHEMBL7815172 0.84 RORC (0.61) RORCBDKRB2
SCHEMBL7815175 0.84 RORC (0.57) RORCBDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874841-B1 1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS FOURNIER IND & SANTE (FR) 2001-10-04 EP disclosed
US-6211181-B1 ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIALLERGENS, AND ANTIASTHMATICS FOURNIER INDUSTRIE ET SANTE (FR) 2001-04-03 US disclosed