Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.61 |
| ▸ | EDNRB | P24530 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27456073 | 0.88 | EDNRA (0.52) | EDNRAEDNRBL3MBTL1GID4GABRA1 | |
| SCHEMBL27324531 | 0.85 | EDNRA (0.52) | EDNRATSHRKMT2AFABP7FABP5 | |
| SCHEMBL8626412 | 0.81 | GABRA1 (0.48) | EDNRAEDNRBGABRA1GABRB2 | |
| SCHEMBL27569651 | 0.78 | EDNRA (0.52) | EDNRAEDNRBGID4ALDH1A1 | |
| SCHEMBL14489184 | 0.78 | GID4 (0.50) | EDNRAEDNRBGID4GABRA1GABRB2 | |
| SCHEMBL27470997 | 0.77 | KMT2A (0.45) | EDNRAEDNRBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7586063 | 0.76 | EDNRA (1.00) | EDNRAEDNRBTSHRRECQLSMN1; SMN2 | |
| SCHEMBL7586070 | 0.76 | EDNRA (1.00) | EDNRAEDNRBTSHRRECQLSMN1; SMN2 | |
| SCHEMBL7586067 | 0.76 | EDNRA (1.00) | EDNRAEDNRBTSHRRECQLSMN1; SMN2 | |
| SCHEMBL7589806 | 0.76 | EDNRA (1.00) | EDNRAEDNRBTSHRRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612244-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-09-19 | — | — | EP | disclosed |