Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816809 | 0.84 | CA1 (0.49) | ALDH1A1TGFBR1GRM5GAAMRGPRX4 | |
| SCHEMBL1462096 | 0.78 | ABL1 (0.61) | KDM4EALDH1A1LMNATGFBR1ABL1 | |
| Methyl Alcohol SCHEMBL6194861 | 0.76 | ABL1 (0.59) | KDM4EALDH1A1LMNATGFBR1ABL1 | |
| SCHEMBL9271076 | 0.74 | CA12 (0.48) | KDM4EALDH1A1LMNAPOLBGAA | |
| SCHEMBL15239842 | 0.74 | TGFBR1 (0.45) | TGFBR1ABL1GRM5NR4A2RXFP1 | |
| SCHEMBL15240808 | 0.72 | TGFBR1 (0.53) | KDM4EALDH1A1TGFBR1ABL1NR4A2 | |
| SCHEMBL28194744 | 0.72 | TSHR (0.43) | KDM4EALDH1A1LMNAABL1POLB | |
| SCHEMBL123068 | 0.71 | CA1 (0.67) | KDM4EALDH1A1LMNAABL1NR4A2 | |
| SCHEMBL21056841 | 0.70 | TGFBR1 (0.56) | KDM4EALDH1A1LMNATGFBR1ABL1 | |
| SCHEMBL16345011 | 0.70 | TGFBR1 (0.51) | KDM4EALDH1A1TGFBR1ABL1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |