Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077656 | 0.85 | NAMPT (0.54) | TACR1NAMPTGPR119USP30TP53 | |
| SCHEMBL697513 | 0.84 | TP53 (0.59) | TACR1NAMPTGPR119USP30TP53 | |
| SCHEMBL23951735 | 0.84 | TP53 (0.59) | TACR1NAMPTGPR119USP30TP53 | |
| SCHEMBL1751432 | 0.84 | TP53 (0.59) | TACR1NAMPTGPR119USP30TP53 | |
| SCHEMBL3843148 | 0.84 | NAMPT (0.66) | NAMPTGPR119TP53LMNAHPGDS | |
| SCHEMBL18759246 | 0.82 | GPR119 (0.55) | TACR1NAMPTRORCGPR119USP30 | |
| Acetic Acid SCHEMBL29880486 | 0.81 | NAMPT (0.63) | NAMPTGPR119TP53LMNAHPGDS | |
| SCHEMBL8082665 | 0.81 | CCR5 (0.60) | — | |
| SCHEMBL407256 | 0.81 | GPR119 (0.54) | TACR1SLC18A3NAMPTRORCGPR119 | |
| SCHEMBL2242108 | 0.81 | GPR119 (0.54) | TACR1SLC18A3NAMPTRORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009405-A4 | PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6166037-A | Pyrrolidine and piperidine modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-1009405-A1 | PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999009984-A1 | PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1999-03-04 | — | — | WO | disclosed |