Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648834 | 0.94 | MAOA (0.44) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL4896837 | 0.85 | GAA (0.51) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL1588016 | 0.84 | MAOA (0.52) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL4581280 | 0.84 | MAOA (0.52) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL268688 | 0.84 | MAOA (0.52) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL4896945 | 0.82 | GAA (0.52) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL9181453 | 0.82 | KMT2A (0.41) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL7223018 | 0.82 | MEN1 (0.41) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL8347115 | 0.82 | MAOA (0.54) | GAAMAOAMAOBALDH1A1POLB | |
| SCHEMBL29144853 | 0.81 | MAOA (0.42) | GAAMAOAMAOBALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |