Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394870 | 1.00 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6394866 | 1.00 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6839247 | 1.00 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6861590 | 0.88 | ADORA2B (0.48) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6861588 | 0.88 | ADORA2B (0.48) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6861594 | 0.88 | ADORA2B (0.48) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6858809 | 0.87 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6858812 | 0.87 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL6858807 | 0.87 | ADORA2B (0.40) | ADORA2BLMNAKDM4EPOLBAPEX1 | |
| SCHEMBL4334217 | 0.85 | LIPE (0.35) | ADORA2BPOLBL3MBTL1LIPENR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694539-B1 | 7-O-Ethers of taxane derivatives | BRISTOL MYERS SQUIBB CO (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6201140-B1 | ANTITUMOR AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2001-03-13 | — | — | US | disclosed |
| EP-0694539-A1 | 7-o-Ethers of taxane derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |